Teleportato
Since having teleportato in place could bring up a bunch of problems in DST, it has not been added to the game. The main issue I realize that there is, is that if someone could simply teleport to worlds over and over again, it would cluster the host's hard drive memory. The problem of CPU/RAM being clustered can be dealt with by the servers shutting down upon players not being in those world anymore (except perhaps in terms of the day count, which could keep going), so a host could have a world/server cluster of something like this:
World 1 World 2 World 3
Overworld (online, 3 players online) Overworld (shut down, 0 players online) Overworld (open, 2 players online)
Caves (online, 2 players online) Caves (shut down, 0 players online) Caves (open, 0 players online)
The way players would move between servers, (but not returning back, I'm guessing) has many options for mechanization out there, like being able to choose which world to move forward to, or automatically moving to a different server after world-hopping, like from World 1 to World 3, because World 2 has no players in it, but World 3 does... I've no real definitive thought on what I could suggest into this, so I'm up for whatever.
But the problem is, as mentioned earlier; hard drive. So, how could it be made sure that forgotten worlds aren't just there, taking up space? Well, a few suggestions I have is that players could vote for deleting worlds that have no players in them/have not had any players playing on them for a long time (e.g. 100 days or so) and/or perhaps the host could delete specific servers, so then the players would be moved to the next or previous world that has been actively... active, with all of their inventory and progress being saved (and possibly even their current character), just that they're in a different world now. Of course, the teleportato would need to be made an optional feature existent in the game and probably disabled by default so as to not make servers lag extremely just because the person hosting this doesn't have a powerful enough machine.
This would provide a great way for players to stop regenerating worlds from boredom and losing progress and instead, moving to new worlds, exploring, whilst their progress and their inventory stays with them, kind of like in original Don't Starve. This then could be one way of keeping things interesting for players who want that feeling of exploration and starting fresh, whilst their initial progress stays. And, this could also keep players' progress whilst moving worlds for the sake of getting new features from an update into overworld and caves, which would otherwise need to be spawned in or have the entire world regenerated!
Disease
Lets be honest; this thing is annoying as all hell in the beta. Nobody is going to bother digging up all the crops and replant them over and over again, just so they could have supplies like grass and berries supplied continuously... or if you do do this, well, you're probably wasting your time, especially if this is on a public server. At lest from my experience, I've seen players camp at desert in order to get grass and twigs from tumbleweeds and have some twiggy trees around, which don't disease in order to get even more twigs. Oh, and grass geckos in desert also supply a bunch of grass for us there! But even then, grass constantly seems to be a bit of a problem though quite often, whilst twigs seem to be fine regardless...
Anyway, another thing I'd like to bring up is that phlegm, even though it's been in the game since the 2nd DST open beta update due to Eqecus being introduced, it hasn't gotten any uses at all. The only thing you can do with it is eat it or let something else eat it, which is kind of a disapointment for a resource you kind of have to get out of your way to get. Since phlegm is something that has a lot to do with disease or illness in real life, why couldn't it be used in order to prevent disease for a tad bit longer in the game? Like, lets say, you could make a bunch of snot bombs (perhaps 4, like with water balloons) out of 2 mosquito sacks and 1 phlegm, which when thrown at plants or animals (grass geckos) that disease, would keep them from getting diseased for like extra 150 days or so, which is about x5 as much as simply digging them up and replanting them, I believe. This would give a great use for the phlegm AND it would make players cooperate in order to achieve something; instead of individually going out of your way to collect grass and twigs, players would need to cooperate or befriend some animals in order to hunt down a Ewecus to then use its phlegm in keeping their in-base plants from becoming diseased and disappearing as well as perhaps turning already diseased plants into non-diseased.